Overview
SCIENTIFIC SCORE
Likely Ineffective
Based on 1 Research
4
USERS' SCORE
Moderately Good
Based on 11 Reviews
7.9
Supplement Facts
Serving Size: 1 Nugget
Amount Per Serving
%DV
Vitamin B12 (as methylcobalamin)
1000 mcg
41,667%
Top Medical Research Studies
4
Vitamin B12's unclear impact on glioblastoma
We explored the effects of vitamin B12 (cobalamin) supplementation on a human glioblastoma cell line known as U-87 MG. Our main goal was to understand how cobalamin, particularly in combination with pyridoxine (vitamin B6), influences cell viability and the process of cell death, known as apoptosis.
Our approach involved treating the glioblastoma cells with varying concentrations of vitamin B12 over a period of 24 to 72 hours. We assessed the health of the cells and their progression through the cell cycle using methods like spectrophotometry and flow cytometry. We also measured specific proteins associated with cell survival and death through western blot analysis.
We found that while vitamin B6 supplementation led to decreased cell viability and increased signs of apoptosis, the role of vitamin B12 was less clear. It appeared that cobalamin did not significantly enhance or inhibit cell death on its own. However, when combined with pyridoxine, it seemed to reduce the cytotoxic effects of vitamin B6.
In summary, while vitamin B12 in isolation did not show a direct benefit for the glioblastoma cells in our study, its potential to influence the effects of other vitamins highlights a complex interaction deserving of further exploration.
Our approach involved treating the glioblastoma cells with varying concentrations of vitamin B12 over a period of 24 to 72 hours. We assessed the health of the cells and their progression through the cell cycle using methods like spectrophotometry and flow cytometry. We also measured specific proteins associated with cell survival and death through western blot analysis.
We found that while vitamin B6 supplementation led to decreased cell viability and increased signs of apoptosis, the role of vitamin B12 was less clear. It appeared that cobalamin did not significantly enhance or inhibit cell death on its own. However, when combined with pyridoxine, it seemed to reduce the cytotoxic effects of vitamin B6.
In summary, while vitamin B12 in isolation did not show a direct benefit for the glioblastoma cells in our study, its potential to influence the effects of other vitamins highlights a complex interaction deserving of further exploration.
Most Useful Reviews
9
Energising recovery
33 people found this helpful
Miraculously, after trying various brands without success for stress relief and brain recovery, this product proved transformative. Immediate effects were evident once I resumed taking the sweet pink tablet; I was very sleepy, which seemed necessary for my recovery. A weekend of rest led to a refreshing revitalisation thereafter. I'm continually impressed by the high quality of Solgar products compared to others.
9
Enhanced energy levels
1 people found this helpful
Iâm a verified purchaser, and I've found this product effective! My brain has been activated, energy levels have surged, and feelings of depression have lifted. Itâs tasty too!
6
Less brain fog
36 people found this helpful
A find for people with digestive troubles. This sublingual form effectively addresses the deficiency it targets. It enhances stomach acid production and works well with B9. Once I've resolved these vitamin deficiencies, I managed to restore my iron levels. I noticed a reduction in brain fog and felt more energetic. The bright red tip of my tongue has returned to normal. Overall, I didnât observe any other significant changes. Some suggest that higher dosages may not be absorbed effectively; I'm uncertain about the truth of this claim.
Medical Researches
SCIENTIFIC SCORE
Likely Ineffective
Based on 1 Research
4
- All Researches
4
Vitamin B12's unclear impact on glioblastoma
We explored the effects of vitamin B12 (cobalamin) supplementation on a human glioblastoma cell line known as U-87 MG. Our main goal was to understand how cobalamin, particularly in combination with pyridoxine (vitamin B6), influences cell viability and the process of cell death, known as apoptosis.
Our approach involved treating the glioblastoma cells with varying concentrations of vitamin B12 over a period of 24 to 72 hours. We assessed the health of the cells and their progression through the cell cycle using methods like spectrophotometry and flow cytometry. We also measured specific proteins associated with cell survival and death through western blot analysis.
We found that while vitamin B6 supplementation led to decreased cell viability and increased signs of apoptosis, the role of vitamin B12 was less clear. It appeared that cobalamin did not significantly enhance or inhibit cell death on its own. However, when combined with pyridoxine, it seemed to reduce the cytotoxic effects of vitamin B6.
In summary, while vitamin B12 in isolation did not show a direct benefit for the glioblastoma cells in our study, its potential to influence the effects of other vitamins highlights a complex interaction deserving of further exploration.
Our approach involved treating the glioblastoma cells with varying concentrations of vitamin B12 over a period of 24 to 72 hours. We assessed the health of the cells and their progression through the cell cycle using methods like spectrophotometry and flow cytometry. We also measured specific proteins associated with cell survival and death through western blot analysis.
We found that while vitamin B6 supplementation led to decreased cell viability and increased signs of apoptosis, the role of vitamin B12 was less clear. It appeared that cobalamin did not significantly enhance or inhibit cell death on its own. However, when combined with pyridoxine, it seemed to reduce the cytotoxic effects of vitamin B6.
In summary, while vitamin B12 in isolation did not show a direct benefit for the glioblastoma cells in our study, its potential to influence the effects of other vitamins highlights a complex interaction deserving of further exploration.
User Reviews
USERS' SCORE
Moderately Good
Based on 11 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Energising recovery
33 people found this helpful
Miraculously, after trying various brands without success for stress relief and brain recovery, this product proved transformative. Immediate effects were evident once I resumed taking the sweet pink tablet; I was very sleepy, which seemed necessary for my recovery. A weekend of rest led to a refreshing revitalisation thereafter. I'm continually impressed by the high quality of Solgar products compared to others.
9
Enhanced energy levels
1 people found this helpful
Iâm a verified purchaser, and I've found this product effective! My brain has been activated, energy levels have surged, and feelings of depression have lifted. Itâs tasty too!
6
Less brain fog
36 people found this helpful
A find for people with digestive troubles. This sublingual form effectively addresses the deficiency it targets. It enhances stomach acid production and works well with B9. Once I've resolved these vitamin deficiencies, I managed to restore my iron levels. I noticed a reduction in brain fog and felt more energetic. The bright red tip of my tongue has returned to normal. Overall, I didnât observe any other significant changes. Some suggest that higher dosages may not be absorbed effectively; I'm uncertain about the truth of this claim.
7.5
Repairs brain synapses
1 people found this helpful
This product facilitates the intake of B12, essential for repairing damaged synapses in the brain due to the Mthr gene, which inhibits B12 uptake.
6
More brain clarity
1 people found this helpful
Excellent Purchase! Iâm really pleased with these B12 sublingual nuggets. They are top-notch quality, have great ingredients, are well-packaged, small, and taste delightful. A couple of days after taking them, I felt the effects of the vitaminâmuch more energy, higher metabolism, and improved brain clarity linked to enhanced nervous system activity. I highly recommend this product.
Frequently Asked Questions
9
Energising recovery
33 people found this helpful
Miraculously, after trying various brands without success for stress relief and brain recovery, this product proved transformative. Immediate effects were evident once I resumed taking the sweet pink tablet; I was very sleepy, which seemed necessary for my recovery. A weekend of rest led to a refreshing revitalisation thereafter. I'm continually impressed by the high quality of Solgar products compared to others.
6
More brain clarity
1 people found this helpful
Excellent Purchase! Iâm really pleased with these B12 sublingual nuggets. They are top-notch quality, have great ingredients, are well-packaged, small, and taste delightful. A couple of days after taking them, I felt the effects of the vitaminâmuch more energy, higher metabolism, and improved brain clarity linked to enhanced nervous system activity. I highly recommend this product.
7.5
Helps B12 levels
2 people found this helpful
Very Good. I havenât received these nuggets yet, but Iâve used sublingual B12 before due to B12 deficiency anaemia and managed to resolve the anaemia with them. You've just got to be consistent and supplement daily until you raise your B12 levels. Vitamin B12 deficiency can affect the brain and nervous system in various ways, and the neurological symptoms can significantly differ.
7.5
Mood improvement
The quality is commendable, with well-researched ingredients. Using the maximum dose has significantly lifted my mood, enhanced focus, and increased energy levels. I also noticed a slight decrease in cholesterol and stress, alongside more active brain function.
6
Less brain fog
36 people found this helpful
A find for people with digestive troubles. This sublingual form effectively addresses the deficiency it targets. It enhances stomach acid production and works well with B9. Once I've resolved these vitamin deficiencies, I managed to restore my iron levels. I noticed a reduction in brain fog and felt more energetic. The bright red tip of my tongue has returned to normal. Overall, I didnât observe any other significant changes. Some suggest that higher dosages may not be absorbed effectively; I'm uncertain about the truth of this claim.
7.5
Repairs brain synapses
1 people found this helpful
This product facilitates the intake of B12, essential for repairing damaged synapses in the brain due to the Mthr gene, which inhibits B12 uptake.
9
Enhanced energy levels
1 people found this helpful
Iâm a verified purchaser, and I've found this product effective! My brain has been activated, energy levels have surged, and feelings of depression have lifted. Itâs tasty too!
4
Vitamin B12's unclear impact on glioblastoma
We explored the effects of vitamin B12 (cobalamin) supplementation on a human glioblastoma cell line known as U-87 MG. Our main goal was to understand how cobalamin, particularly in combination with pyridoxine (vitamin B6), influences cell viability and the process of cell death, known as apoptosis.
Our approach involved treating the glioblastoma cells with varying concentrations of vitamin B12 over a period of 24 to 72 hours. We assessed the health of the cells and their progression through the cell cycle using methods like spectrophotometry and flow cytometry. We also measured specific proteins associated with cell survival and death through western blot analysis.
We found that while vitamin B6 supplementation led to decreased cell viability and increased signs of apoptosis, the role of vitamin B12 was less clear. It appeared that cobalamin did not significantly enhance or inhibit cell death on its own. However, when combined with pyridoxine, it seemed to reduce the cytotoxic effects of vitamin B6.
In summary, while vitamin B12 in isolation did not show a direct benefit for the glioblastoma cells in our study, its potential to influence the effects of other vitamins highlights a complex interaction deserving of further exploration.
Our approach involved treating the glioblastoma cells with varying concentrations of vitamin B12 over a period of 24 to 72 hours. We assessed the health of the cells and their progression through the cell cycle using methods like spectrophotometry and flow cytometry. We also measured specific proteins associated with cell survival and death through western blot analysis.
We found that while vitamin B6 supplementation led to decreased cell viability and increased signs of apoptosis, the role of vitamin B12 was less clear. It appeared that cobalamin did not significantly enhance or inhibit cell death on its own. However, when combined with pyridoxine, it seemed to reduce the cytotoxic effects of vitamin B6.
In summary, while vitamin B12 in isolation did not show a direct benefit for the glioblastoma cells in our study, its potential to influence the effects of other vitamins highlights a complex interaction deserving of further exploration.
References
- MartĂnez-Mendiola CA, Estrada JA, Zapi-ColĂn LĂ, Contreras-ChĂĄvez GG, Contreras I. Effect of pyridoxine or cobalamin supplementation on apoptosis and cell cycle progression in a human glioblastoma cell line. Int J Neurosci. 2024;134:1320. 10.1080/00207454.2023.2263815
